Blar i forfatter "Hadi, Ali Muataz"
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The search of new negative allosteric GABAB receptor modulators using in silico and in vitro approaches
Hadi, Ali Muataz (Mastergradsoppgave; Master thesis, 2020-05-14)γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the CNS. GABA exerts its function on both ionotropic ligand-gated GABAA receptors and metabotropic GABAB G-protein coupled receptors (GPCRs). Disruption in the GABAergic system has been associated with numerous neurological and psychiatric disorders in humans. These include developmental dysfunctions, epilepsy, sleep disorders, ...